http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID410975
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Peptidase C80 cysteine binding domain of Clostridium difficile toxins A and B, and related proteins. This peptidase C80 family includes the major virulence factors of Clostridium difficile multidomain toxins TcdA and TcdB. These large homologous toxins contain several distinct domains including a cysteine protease domain (CPD) that autoproteolytically releases a cytotoxic effector domain upon binding of intracellular inositol hexakisphosphate. C. difficile is a major cause of intestinal tissue damage and inflammation, and TcdA is generally more inflammatory whereas TcdB is more cytotoxic; studies show that the CPD is an internal regulator of the proinflammatory activity. Site-directed mutagenesis has identified functional residues Asp/His/Cys in Clostridium toxin B. |
| title | C80_toxinA_B-like |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25640777 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26904530 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13380381 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6342763 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15688004 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20445065 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4530557 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18062234 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3088459 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29152979 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6216268 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18728427 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP18177 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC3PA8_A http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP16154 |
Total number of triples: 18.