conserveddomain/PSSMID410974

Predicate	Object
abstract	peptidase C80 cysteine binding domain of RTX toxin RtxA and related proteins. This peptidase C80 family includes the autoproteolytic cysteine protease domain (CPD) of Vibrio cholerae multifunctional autoprocessing repeats-in-toxin (MARTX) toxin that causes disassembly of the actin cytoskeleton and enhances V. cholerae colonization of the small intestine, possibly by facilitating evasion of phagocytic cells. The central region of this toxin is composed of several domains, including the actin cross-linking domain (ACD) that introduces lysine-glutamate cross-links between actin protomers, the Rho-inactivating domain (RID) that disables small Rho GTPases, and an autoprocessing cysteine protease domain (CPD). Within the cell, the CPD is activated by the binding of inositol hexakisphosphate to release individual effector domains of the toxin into the cytosol. The CPD contains the characteristic Cys/His residues in the active site.
title	C80_RtxA-like
isDiscussedBy	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26872046 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10623046 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3088459
type	http://purl.obolibrary.org/obo/SO_0000417

Predicate	Subject
has component	http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC3EEB_A http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC3FZY_A

Total number of triples: 8.