http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID410630
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors. This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. |
| title | 7tmA_FMRFamide_R-like |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13395088 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32849783 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26854663 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1802510 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2688610 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16322106 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22848632 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6414673 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9352784 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20772813 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22821311 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24222127 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26865219 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16758891 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18757982 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20185704 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26270988 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4532126 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26874349 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15694354 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24763219 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3733537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28907367 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30912118 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13343446 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19286901 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9VZW5 |
Total number of triples: 30.