http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID410539
Outgoing Links
Predicate | Object |
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abstract | second Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins. JMJD2C, also called lysine-specific demethylase 4C (KDM4C), gene amplified in squamous cell carcinoma 1 protein (GASC-1 protein), or JmjC domain-containing histone demethylation protein 3C (JHDM3C), is an epigenetic factor that catalyzes the demethylation of di- and trimethylated H3K9 and H3K36, and may be involved in the development and/or progression of various types of cancer including esophageal squamous cell carcinoma (ESC) and breast cancer. It selectively interacts with hypoxia-inducible factor 1alpha (HIF1alpha) and plays a role in breast cancer progression. Moreover, JMJD2C may play an important role in the treatment of obesity and its complications by modulating the regulation of adipogenesis by nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma). JMJD2C contains jmjN and jmjC domains in the N-terminal region, followed by a canonical plant homeodomain (PHD) domain, a noncanonical extended PHD domain, and tandem Tudor domains. The model corresponds to the second Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. |
title | Tudor_JMJD2C_rpt2 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31615626 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33640090 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33535838 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26204672 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23506605 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32916123 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2369517 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1792601 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4395469 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21956177 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5103917 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4384068 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8659725 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30841439 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28870007 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_055876 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9H3R0 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCAAI43572 |
Total number of triples: 21.