http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID410424

Outgoing Links

Predicate Object
abstract protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 1 (ROCK1) and similar proteins. ROCK1 is a serine/threonine kinase, catalyzing the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1, also called Rho-associated protein kinase 1, renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase I (ROCK-I), p160 ROCK-1, or p160ROCK, is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK proteins contain an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD), a pleckstrin homology (PH) domain and a C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
title C1_ROCK1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11937314
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26129335
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21393003
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22726238
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20727929
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26807919
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27488533
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22729824
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27505742
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27419668
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33534189
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15315439
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19381106
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20726525
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32848977
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP70335
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_005397
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ13464

Total number of triples: 21.