http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID410393
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins. PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites. |
| title | C1_PKD2_rpt2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6618153 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9895152 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1122499 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23411065 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29475136 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16700562 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13615481 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6728385 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31689397 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5086957 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17969500 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25143397 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26166222 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21297575 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18043075 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/234229 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18032948 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2388951 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 24.