http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID410309
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins. RBL2, also called 130 kDa retinoblastoma-associated protein (p130), retinoblastoma-related protein 2 (RBR-2), or pRb2, is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure, especially that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It may also act as a tumor suppressor. RBL2 contains one cyclin box. The cyclin box is a protein binding domain. |
| title | CYCLIN_RBL2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13122816 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14459343 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24019154 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27998723 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25107685 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30839293 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14459342 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25124195 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/217327 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ08999 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ64700 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO55081 |
Total number of triples: 15.