http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID409865
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins. This subfamily corresponds to the RRM of ALKBH8, also termed alpha-ketoglutarate-dependent dioxygenase ABH8, or S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, expressed in various types of human cancers. It is essential in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals. ALKBH8 has also been identified as a tRNA methyltransferase that catalyzes methylation of tRNA to yield 5-methylcarboxymethyl uridine (mcm5U) at the wobble position of the anticodon loop. Thus, ALKBH8 plays a crucial role in the DNA damage survival pathway through a distinct mechanism involving the regulation of tRNA modification. ALKBH8 localizes to the cytoplasm. It contains the characteristic AlkB domain that is composed of a tRNA methyltransferase motif, a motif homologous to the bacterial AlkB DNA/RNA repair enzyme, and a dioxygenase catalytic core domain encompassing cofactor-binding sites for iron and 2-oxoglutarate. In addition, unlike other AlkB homologs, ALKBH8 contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal S-adenosylmethionine (SAM)-dependent methyltransferase (MT) domain. |
| title | RRM_ALKBH8 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18713054 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22131318 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22833269 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5217198 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17395326 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23490973 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31603032 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/434018 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ96BT7 |
Total number of triples: 12.