http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID409840
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | RNA recognition motif 4 (RRM4) found in vertebrate nucleolin. This subfamily corresponds to the RRM4 of ubiquitously expressed protein nucleolin, also termed protein C23, is a multifunctional major nucleolar phosphoprotein that has been implicated in various metabolic processes, such as ribosome biogenesis, cytokinesis, nucleogenesis, cell proliferation and growth, cytoplasmic-nucleolar transport of ribosomal components, transcriptional repression, replication, signal transduction, inducing chromatin decondensation, etc. Nucleolin exhibits intrinsic self-cleaving, DNA helicase, RNA helicase and DNA-dependent ATPase activities. It can be phosphorylated by many protein kinases, such as the major mitotic kinase Cdc2, casein kinase 2 (CK2), and protein kinase C-zeta. Nucleolin shares similar domain architecture with gar2 from Schizosaccharomyces pombe and NSR1 from Saccharomyces cerevisiae. The highly phosphorylated N-terminal domain of nucleolin is made up of highly acidic regions separated from each other by basic sequences, and contains multiple phosphorylation sites. The central domain of nucleolin contains four closely adjacent N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), which suggests that nucleolin is potentially able to interact with multiple RNA targets. The C-terminal RGG (or GAR) domain of nucleolin is rich in glycine, arginine and phenylalanine residues, and contains high levels of NG,NG-dimethylarginines. |
| title | RRM4_NCL |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33488640 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7909333 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9105600 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22833269 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5111451 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22733658 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/434018 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26681355 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19380199 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11076401 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3742032 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4747263 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1401298 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19192698 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 25.