http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID409499
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1); member of the I-set of Ig superfamily (IgSF) domains. The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1). VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. VEGFRs bind VEGFs with high affinity at the Ig-like domains. VEGFR-1 binds VEGF-A strongly; VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-1 may play an inhibitory role in the function of VEGFR-2 by binding VEGF-A and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis and may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand. |
| title | IgI_VEGFR-1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9726963 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9726962 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27419701 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/208670 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29507003 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21894000 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9080750 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20007679 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15142594 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13851562 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 16.