http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID409448
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains. The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth. |
| title | IgI_VEGFR |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5128789 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10586411 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13851562 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/208670 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27419701 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9726963 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21894000 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20007679 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10586973 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15142594 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 25.