http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID409429
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains. The members here are composed of the immunoglobulin (Ig)-like domain in Signal-Regulatory Protein (SIRP), domain 2 (C1 repeat 1). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three Immunoglobulin superfamily domains, a single V-set and two C1-set IgSF domains. Their cytoplasmic tails contain either ITIMs or transmembrane regions that have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47, but with much less affinity. |
| title | IgC1_SIRP_domain_2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16325948 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21894000 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25145303 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25373860 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13851562 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18641915 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15198430 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12471068 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/208670 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31370072 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4857162 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8446125 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 21.