http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID380979
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins. SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML). |
| title | SET_SMYD2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31555250 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7281470 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17409353 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22785988 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10119157 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12691945 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5794627 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 18.