http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID380900

Outgoing Links

Predicate Object
abstract B-box-type 1 zinc finger found in tripartite motif-containing proteins, TRIM25, TRIM47 and similar proteins. The family includes tripartite motif-containing proteins, TRIM25 and TRIM47, both of which belong to the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, Bbox1 and Bbox2, and a coiled coil region, as well as a SPRY/B30.2 domain positioned C-terminal to the RBCC domain. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif. TRIM25, also termed estrogen-responsive finger protein (EFP), or ubiquitin/ISG15-conjugating enzyme TRIM25, or zinc finger protein 147 (ZNF147), or E3 ubiquitin/ISG15 ligase TRIM25, is induced by estrogen and is particularly abundant in placenta and uterus. It has been implicated in cell proliferation, protein modification, and the retinoic acid inducible gene I (RIG-I)-mediated antiviral signaling pathway. It functions as an E3-ubiquitin ligase able to transfer ubiquitin and ISG15 to target proteins. TRIM47, also known as gene overexpressed in astrocytoma protein (GOA) or RING finger protein 100 (RNF100), plays an important role in the process of dedifferentiation that is associated with astrocytoma tumorigenesis.
title Bbox1_TRIM25-like_C-IV
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16151122
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16805866
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20886685
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4376464
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10615504
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/900807
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18519824
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24908854
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22087780
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5117815
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26861451
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24290029
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25644139
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7210222
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20197724
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18004326
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31021308
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31680738
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33680172
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ61510
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ14258

Total number of triples: 24.