http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID350856
Outgoing Links
Predicate | Object |
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abstract | heme oxygenase in eukaryotes and some bacteria. This subfamily contains heme oxygenase (HO, EC 1.14.14.18) found in eukaryotes as well as some proteobacteria, including cyanobacteria. Heme oxygenase (HO) catalyzes the rate limiting step in the degradation of heme to biliverdin in a multi-step reaction. HO is essential for recycling of iron from heme which is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. In vertebrates, HO plays a role in heme homeostasis and oxidative stress response, and cellular signaling in mammals that include isoforms HO-1, HO-2 and HO-3. HO-1 is ubiquitously expressed after induction while HO-2 expression is constitutive, mostly limited to certain organs, such as the brain, testes, and the vascular system. HO-3 is non-functional in humans, suggesting that the Hmox3 gene is a pseudogene derived from HO-2 transcripts. In higher plants and cyanobacteria, heme oxygenase is required for the synthesis of light-harvesting pigments, which contain tetrapyrrols derived from biliverdin. Candida albicans expresses a heme oxygenase that is required for the utilization of heme as a nutritional iron source, whereas Saccharomyces cerevisiae responds to iron deprivation by increasing Hmx1p transcription, which is controlled by the major iron-dependent transcription factor, Aft1p, and promotes both the re-utilization of heme iron and the regulation of heme-dependent transcription during periods of iron scarcity. In pathogenic bacteria, HO is part of a pathway for iron acquisition from host heme. In Leptospira interrogans, a pathogenic spirochete that causes leptospirosis, HO is required for iron utilization when hemoglobin is the sole iron source, thus making HO an interesting target for novel antimicrobial agents. HO shares tertiary structure similarity to methane monooxygenase (EC 1.14.13.25), ribonucleotide reductase (EC 1.17.4.1) and thiaminase II (EC 3.5.99.2), but shares little sequence homology. |
title | HemeO |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11841482 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2962323 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27379851 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22050395 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23059065 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2578624 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19453225 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/53081 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11820061 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11426363 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22293915 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11148149 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6426376 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22253930 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21275894 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/250699 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24083079 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22623771 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19254384 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26770688 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19337663 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1738068 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15910243 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12581996 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19248264 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15908142 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17235381 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14157216 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5689746 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13832637 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10577674 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15217439 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20534868 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3233468 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18045094 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO48782 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9C9L4 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9LQC0 |
Total number of triples: 41.