http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID350856

Outgoing Links

Predicate Object
abstract heme oxygenase in eukaryotes and some bacteria. This subfamily contains heme oxygenase (HO, EC 1.14.14.18) found in eukaryotes as well as some proteobacteria, including cyanobacteria. Heme oxygenase (HO) catalyzes the rate limiting step in the degradation of heme to biliverdin in a multi-step reaction. HO is essential for recycling of iron from heme which is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. In vertebrates, HO plays a role in heme homeostasis and oxidative stress response, and cellular signaling in mammals that include isoforms HO-1, HO-2 and HO-3. HO-1 is ubiquitously expressed after induction while HO-2 expression is constitutive, mostly limited to certain organs, such as the brain, testes, and the vascular system. HO-3 is non-functional in humans, suggesting that the Hmox3 gene is a pseudogene derived from HO-2 transcripts. In higher plants and cyanobacteria, heme oxygenase is required for the synthesis of light-harvesting pigments, which contain tetrapyrrols derived from biliverdin. Candida albicans expresses a heme oxygenase that is required for the utilization of heme as a nutritional iron source, whereas Saccharomyces cerevisiae responds to iron deprivation by increasing Hmx1p transcription, which is controlled by the major iron-dependent transcription factor, Aft1p, and promotes both the re-utilization of heme iron and the regulation of heme-dependent transcription during periods of iron scarcity. In pathogenic bacteria, HO is part of a pathway for iron acquisition from host heme. In Leptospira interrogans, a pathogenic spirochete that causes leptospirosis, HO is required for iron utilization when hemoglobin is the sole iron source, thus making HO an interesting target for novel antimicrobial agents. HO shares tertiary structure similarity to methane monooxygenase (EC 1.14.13.25), ribonucleotide reductase (EC 1.17.4.1) and thiaminase II (EC 3.5.99.2), but shares little sequence homology.
title HemeO
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11841482
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2962323
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27379851
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22050395
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23059065
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2578624
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19453225
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/53081
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11820061
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11426363
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22293915
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11148149
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6426376
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22253930
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21275894
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/250699
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24083079
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22623771
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19254384
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26770688
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19337663
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1738068
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15910243
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12581996
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19248264
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15908142
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17235381
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14157216
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5689746
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13832637
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10577674
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15217439
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20534868
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3233468
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18045094
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO48782
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9C9L4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9LQC0

Total number of triples: 41.