http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID349465
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup. Peptidase M14 Carboxypeptidase (CP) B2 (CPB2, also known as plasma carboxypeptidase B, carboxypeptidase U, and CPU), belongs to the carboxpeptidase A/B subfamily of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPB2 enzyme displays B-like activity; it only cleaves the basic residues lysine or arginine. It is produced and secreted by the liver as the inactive precursor, procarboxypeptidase U or PCPB2, commonly referred to as thrombin-activatable fibrinolysis inhibitor (TAFI). It circulates in plasma as a zymogen bound to plasminogen, and the active enzyme, TAFIa, inhibits fibrinolysis. It is highly regulated, increased TAFI concentrations are thought to increase the risk of thrombosis and coronary artery disease by reducing fibrinolytic activity while low TAFI levels have been correlated with chronic liver disease. |
| title | M14_CPB2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30756681 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26814426 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29503493 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9862649 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29518389 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28719162 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23255030 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15298598 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23303261 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 17.