http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID349431
Outgoing Links
Predicate | Object |
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abstract | Peptidase M14 carboxypeptidase subfamily N/E-like. Carboxypeptidase (CP) N/E-like subfamily of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes eight members, of which five (CPN, CPE, CPM, CPD, CPZ) are considered enzymatically active, while the other three are non-active (CPX1, PCX2, ACLP/AEBP1) and lack the critical active site and substrate-binding residues considered necessary for CP activity. These non-active members may function as binding proteins or display catalytic activity towards other substrates. Unlike the A/B CP subfamily, enzymes belonging to the N/E subfamily are not produced as inactive precursors that require proteolysis to produce the active form; rather, they rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell. In addition, all members of the N/E subfamily contain an extra C-terminal domain that is not present in the A/B subfamily. This domain has structural homology to transthyretin and other proteins and has been proposed to function as a folding domain. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. |
title | M14_CP_N-E_like |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22621433 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9762924 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28719162 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33509113 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19380557 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25135816 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10447532 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15298598 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23255030 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21277287 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20010721 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26158942 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28856329 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5104503 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16576328 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31530393 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23303261 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22061172 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13979893 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18554718 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7072541 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29503493 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13277213 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26154660 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14510464 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29518389 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22650990 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO17754 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP42787 |
Total number of triples: 32.