http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID349431

Outgoing Links

Predicate Object
abstract Peptidase M14 carboxypeptidase subfamily N/E-like. Carboxypeptidase (CP) N/E-like subfamily of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes eight members, of which five (CPN, CPE, CPM, CPD, CPZ) are considered enzymatically active, while the other three are non-active (CPX1, PCX2, ACLP/AEBP1) and lack the critical active site and substrate-binding residues considered necessary for CP activity. These non-active members may function as binding proteins or display catalytic activity towards other substrates. Unlike the A/B CP subfamily, enzymes belonging to the N/E subfamily are not produced as inactive precursors that require proteolysis to produce the active form; rather, they rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell. In addition, all members of the N/E subfamily contain an extra C-terminal domain that is not present in the A/B subfamily. This domain has structural homology to transthyretin and other proteins and has been proposed to function as a folding domain. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation.
title M14_CP_N-E_like
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22621433
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9762924
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28719162
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33509113
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19380557
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25135816
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10447532
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15298598
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23255030
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21277287
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20010721
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26158942
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28856329
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5104503
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16576328
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31530393
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23303261
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22061172
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13979893
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18554718
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7072541
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29503493
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13277213
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26154660
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14510464
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29518389
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22650990
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO17754
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP42787

Total number of triples: 32.