http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID340806
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA1. ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, Gamma-ear-containing, Arf-binding 1) is also called Gamma-adaptin-related protein 1. It is expressed in human brain and affects the generation of amyloid beta-peptide, and may be involved in the pathogenesis of Alzheimer disease. It is a member of the GGA subfamily, which is comprised of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins involved in membrane trafficking between the Trans-Golgi Network (TGN) and endosomes. The VHS domain has a superhelical structure similar to the structure of the ARM (Armadillo) repeats and is present at the N-termini of proteins. GGA proteins have a multidomain structure consisting of an N-terminal VHS domain linked by a short proline-rich linker to a GAT (GGA and TOM) domain, which is followed by a long flexible linker to the C-terminal appendage, GAE (Gamma-Adaptin Ear) domain. The VHS domain of GGA proteins binds to the acidic-cluster dileucine (DxxLL) motif found on the cytoplasmic tails of cargo proteins trafficked between the Trans-Golgi Network and the endosomal system. |
| title | VHS_GGA1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19374536 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4364089 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11937235 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21997174 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8627835 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33434967 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11185839 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13881393 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20013124 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30299709 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32097465 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27496549 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20724663 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33488691 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11120463 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC1PY1_A |
Total number of triples: 19.