http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID340797
Outgoing Links
Predicate | Object |
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abstract | VHS (Vps27/Hrs/STAM) domain of Signal Transducing Adapter Molecule 1. Signal Transducing Adapter Molecule 1 (STAM1) is part of a crucial regulatory axis for the ventral axonal trajectory of developing spinal motor neurons. It forms a complex with beta-arrestin, which regulates lysosomal trafficking of the chemokine receptor CXCR4 and also mediates CXCR4-dependent chemotaxis. STAM (Signal Transducing Adaptor Molecule) subfamily members have at their N-termini a VHS domain, which is involved in cytokine-mediated intracellular signal transduction and has a superhelical structure similar to the structure of ARM (Armadillo) repeats, followed by a Ubiquitin-Interacting Motif (UIM) and a SH3 (Src Homology 3) domain, which is a well-established protein-protein interaction domain, and a GAT (GGA and TOM) domain. At the C-termini of most vertebrate STAMS, an Immunoreceptor Tyrosine-based Activation Motif (ITAM) is present, which mediates the binding of HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) in endocytic and exocytic machineries. STAM is a component of the ESCRT (Endosomal Sorting Complex Required for Transport)-0 machinery and together with Hrs, functions to bind and sequester cargoes for downstream sorting into intralumenal vesicles. |
title | VHS_STAM1 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13881393 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18601710 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11120463 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9961338 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15155604 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31726471 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21997174 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6371158 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33385278 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8076485 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27536708 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ92783 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP70297 |
Total number of triples: 16.