http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID340797

Outgoing Links

Predicate Object
abstract VHS (Vps27/Hrs/STAM) domain of Signal Transducing Adapter Molecule 1. Signal Transducing Adapter Molecule 1 (STAM1) is part of a crucial regulatory axis for the ventral axonal trajectory of developing spinal motor neurons. It forms a complex with beta-arrestin, which regulates lysosomal trafficking of the chemokine receptor CXCR4 and also mediates CXCR4-dependent chemotaxis. STAM (Signal Transducing Adaptor Molecule) subfamily members have at their N-termini a VHS domain, which is involved in cytokine-mediated intracellular signal transduction and has a superhelical structure similar to the structure of ARM (Armadillo) repeats, followed by a Ubiquitin-Interacting Motif (UIM) and a SH3 (Src Homology 3) domain, which is a well-established protein-protein interaction domain, and a GAT (GGA and TOM) domain. At the C-termini of most vertebrate STAMS, an Immunoreceptor Tyrosine-based Activation Motif (ITAM) is present, which mediates the binding of HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) in endocytic and exocytic machineries. STAM is a component of the ESCRT (Endosomal Sorting Complex Required for Transport)-0 machinery and together with Hrs, functions to bind and sequester cargoes for downstream sorting into intralumenal vesicles.
title VHS_STAM1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13881393
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18601710
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11120463
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9961338
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15155604
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31726471
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21997174
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6371158
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33385278
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8076485
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27536708
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ92783
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP70297

Total number of triples: 16.