http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID340693

Outgoing Links

Predicate Object
abstract FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1). TLN1 is a cytoskeletal protein that plays a pivotal role in regulating the activity of the integrin family of cell adhesion proteins by coupling them to F-actin. It functions as a focal adhesion protein involved in the attachment of the bacterium. It binds to multiple adhesion molecules, including integrins, vinculin, focal adhesion kinase (FAK), and actin. TLN1 also plays an essential role in integrin activation. TLN1 interacts with the hepatitis B virus (HBV) accessory protein X (HBx), which induces the degradation of TLN1. It also acts as an adaptor protein that regulates leukocyte function-associated antigen-1 (LFA-1) affinity. In addition, TLN1 is required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. TLN1 consists of an N-terminal head and a C-terminal rod. The talin head harbors a FERM (Band 4.1, ezrin, radixin, moesin) domain made up of F1, F2 and F3 domains, as well as an N-terminal region that precedes the FERM domain and has been referred to as the F0 domain. Both F0 and F1 domains have similar ubiquitin-like folds. This family corresponds to the F1 domain.
title FERM_F1_TLN1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11800693
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8077013
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9366802
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32359906
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5987749
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31714641
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9961341
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14830914
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33513294
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25148024
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25519133
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28879041
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4440159
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10789156
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP26039
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9Y490

Total number of triples: 19.