http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID340693
Outgoing Links
Predicate | Object |
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abstract | FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1). TLN1 is a cytoskeletal protein that plays a pivotal role in regulating the activity of the integrin family of cell adhesion proteins by coupling them to F-actin. It functions as a focal adhesion protein involved in the attachment of the bacterium. It binds to multiple adhesion molecules, including integrins, vinculin, focal adhesion kinase (FAK), and actin. TLN1 also plays an essential role in integrin activation. TLN1 interacts with the hepatitis B virus (HBV) accessory protein X (HBx), which induces the degradation of TLN1. It also acts as an adaptor protein that regulates leukocyte function-associated antigen-1 (LFA-1) affinity. In addition, TLN1 is required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. TLN1 consists of an N-terminal head and a C-terminal rod. The talin head harbors a FERM (Band 4.1, ezrin, radixin, moesin) domain made up of F1, F2 and F3 domains, as well as an N-terminal region that precedes the FERM domain and has been referred to as the F0 domain. Both F0 and F1 domains have similar ubiquitin-like folds. This family corresponds to the F1 domain. |
title | FERM_F1_TLN1 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11800693 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8077013 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9366802 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32359906 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5987749 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31714641 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9961341 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14830914 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33513294 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25148024 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25519133 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28879041 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4440159 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10789156 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP26039 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9Y490 |
Total number of triples: 19.