http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID340437
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins. 1-phosphatidylinositol-3-phosphate 5-kinase (EC 2.7.1.150) is also called FYVE finger-containing phosphoinositide kinase, PIKfyve, phosphatidylinositol 3-phosphate 5-kinase (PIP5K3), or phosphatidylinositol 3-phosphate 5-kinase type III (PIPkin-III or type III PIP kinase). It forms a complex with its regulators, the scaffolding protein Vac14 and the lipid phosphatase Fig4. The complex is responsible for synthesizing phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] by catalyzing the phosphorylation of phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) on the fifth hydroxyl of the myo-inositol ring. Then phosphatidylinositol-5-phosphate (PtdIns5P) is generated directly from PtdIns(3,5)P2. PtdIns(3,5)P2 and PtdIns5P regulate endosomal trafficking and responses to extracellular stimuli. PIKfyve is vital in early embryonic development. It forms a complex with ArPIKfyve (associated regulator of PIKfyve) and SAC3 at the endomembranes, playing a role in receptor tyrosine kinase (RTK) degradation. The phosphorylation of PIKfyve by AKT can facilitate epidermal growth factor receptor (EGFR) degradation. In addition, PIKfyve may participate in the regulation of the glutamate transporters EAAT2, EAAT3 and EAAT4, and the cystic fibrosis transmembrane conductance regulator (CFTR). It is also essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle. It can be activated by protein kinase B (PKB/Akt) and further up-regulates human Ether-a-go-go-Related Gene (hERG) channels. This family also includes the yeast ortholog of human PIKfyve, Fab1. PIKfyve and its orthologs share a similar architecture. They contain an N-terminal FYVE domain, a middle region related to the CCT/TCP-1/Cpn60 chaperonins that are involved in productive folding of actin and tubulin, a second middle domain that contains a number of conserved cysteine residues (CCR) unique to this family, and a C-terminal catalytic lipid kinase domain related to PtdInsP kinases (or the PIPKc domain). |
| title | PIPKc_PIKfyve |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32754841 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/371532 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30956524 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3195719 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9137751 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1730623 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17384707 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27480146 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3176698 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14512221 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1720391 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13859900 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16744778 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33645537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28194245 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24238340 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32941164 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7228832 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26150621 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14010628 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20766623 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28920952 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32301218 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24811823 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23243235 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 37.