http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID320680
Outgoing Links
Predicate | Object |
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abstract | Sortase domain found in class A sortases. Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate. |
title | Sortase_A |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3814121 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18187936 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30985132 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5635124 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24265799 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30864967 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25383370 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11147680 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30086217 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2898052 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13883762 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24824871 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1187494 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3794827 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17213008 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32763039 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1024978 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26299483 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13938073 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23504486 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10760261 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4364689 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23613548 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26815338 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32857753 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4420256 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16660460 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24216359 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0DPQ5 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8E5N2 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Y8H5 |
Total number of triples: 34.