http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID320680

Outgoing Links

Predicate Object
abstract Sortase domain found in class A sortases. Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate.
title Sortase_A
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3814121
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18187936
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30985132
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5635124
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24265799
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30864967
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25383370
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11147680
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30086217
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2898052
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13883762
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24824871
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1187494
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3794827
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17213008
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32763039
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1024978
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26299483
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13938073
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23504486
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10760261
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4364689
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23613548
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26815338
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32857753
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4420256
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16660460
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24216359
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0DPQ5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8E5N2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Y8H5

Total number of triples: 34.