http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID320424
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. |
| title | 7tmA_mAChR_M2 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28907367 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10632076 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18757982 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26874349 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26865219 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22848632 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26270988 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4532126 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22821311 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24222127 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3733537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26303145 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22173232 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20772813 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1802510 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24877423 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9352784 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16322457 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16322106 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 36.