http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID320375
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | class F mammalian frizzled subfamily 1, member of 7-transmembrane G protein-coupled receptors. This group includes subfamily 1 of the frizzled (FZD) family of seven transmembrane-spanning proteins, which constitute a novel and separate class of G-protein coupled receptors. This class F protein family consists of 10 isoforms (FZD1-10) in mammals. The FZDs are activated by the wingless/int-1 (WNT) family of secreted lipoglycoproteins and preferentially couple to stimulatory G proteins of the Gs family, which activate adenylate cyclase, but can also couple to G proteins of the Gi/Gq families. In the WNT/beta-catenin signaling pathway, the WNT ligand binds to FZD and a lipoprotein receptor-related protein (LRP) co-receptor. This leads to the stabilization and translocation of beta-catenin to the nucleus, where it induces the activation of TCF/LEF family transcription factors. The conserved cytoplasmic motif of FZD, Lys-Thr-X-X-X-Trp, is required for activation of the WNT/beta-catenin pathway, and for membrane localization and phosphorylation of Dsh (dishevelled) protein, a key component of the WNT pathway that relays the WNT signals from the activated receptor to downstream effector proteins. The WNT pathway plays a critical role in many developmental processes, such as cell-fate determination, cell proliferation, neural patterning, stem cell renewal, tissue homeostasis and repair, and tumorigenesis, among many others. |
| title | 7tmF_FZD1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30697515 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4747047 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4532126 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11101610 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13395088 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22839698 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16322106 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9352784 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28799075 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13343446 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26231099 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16758891 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30912118 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16322457 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21347156 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26889282 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27550888 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3733537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24222127 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15694354 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1802510 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26865219 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 30.