http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID293992
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | PRY/SPRY domain of butyrophilin 3 (BTN3), includes BTN3A1, BTN3A2, BTN3A3 as well as BTN-like 3 (BTNL3); BTN3A also known as CD277. This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of butyrophilin family 3A (BTN3A); duplication events have led to three paralogs in primates: BTN3A1, BTN3A2, and BTN3A3. BTNs belong to receptor glycoproteins of immunoglobulin (Ig) superfamily, characterized by the presence of extracellular Ig-like domains (IgV and/or IgC). BTN3 transcripts are ubiquitously present in all immune cells (T cells, B cells, NK cells, monocytes, dendritic cells, and hematopoietic precursors) with different expression levels; BTN3A1 and BTN3A2 are expressed mainly by CD4+ and CD8+ T cells, BTN3A2 is the major form expressed in NK cells, and BTN3A3 is poorly expressed in these immune cells. The PRY/SPRY domain of the BTN3A1 isoform mediates phosphoantigen (pAg)-induced activation by binding directly to the pAg. |
| title | SPRY_PRY_BTN3 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25129834 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12698319 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18015166 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3841263 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25129557 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1064325 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12062530 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12767271 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24190618 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30994342 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO00481 |
Total number of triples: 14.