http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID293879
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Guanylate-binding protein, C-terminal domain. Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines. |
| title | GBP_C |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2290795 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21265406 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7077911 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29407332 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1080304 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19286693 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5729427 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 16.