conserveddomain/PSSMID277269

Predicate	Object
abstract	FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins. EEA1, also termed endosome-associated protein p162, or zinc finger FYVE domain-containing protein 2, is an essential component of the endosomal fusion machinery and required for the fusion and maturation of early endosomes in endocytosis. It forms a parallel coiled-coil homodimer in cells. EEA1 serves as the p97 ATPase substrate and the p97 ATPase may regulate the size of early endosomes by governing the oligomeric state of EEA1. It can interact with the GTP-bound form of Rab22a and be involved in endosomal membrane trafficking. EEA1 also functions as an obligate scaffold for angiotensin II-induced Akt activation in early endosomes. It can be phosphorylated by p38 mitogen-activated protein kinase (MAPK) and further regulate mu opioid receptor endocytosis. EEA1 consists of an N-terminal C2H2 Zn2+ finger, four long heptad repeats, and a C-terminal region containing a calmodulin binding (IQ) motif, a Rab5 interaction site, and a FYVE domain. This model corresponds to the FYVE domain that is responsible for binding phosphatidyl inositol-3-phosphate (PtdIns3P or PI3P) on the membrane.
title	FYVE_EEA1
type	http://purl.obolibrary.org/obo/SO_0000417

Predicate	Subject
has component	http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACC1JOC_A http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8BL66 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ15075

Total number of triples: 6.