http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID271402
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain. SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. |
| title | SLC5sbd_SMCT1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3056282 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8570408 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28788728 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12596683 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19357446 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21453132 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17248545 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9870710 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16004106 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7882984 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15898509 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24112792 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4392602 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31528621 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11991677 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14038634 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13927582 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 24.