conserveddomain/PSSMID271127

Predicate	Object
abstract	Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
title	PKc_DYRK4
isDiscussedBy	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3744599 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22590236 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13207707 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24695177
type	http://purl.obolibrary.org/obo/SO_0000417

Predicate	Subject
has component	http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_003836 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9NR20

Total number of triples: 9.