http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID271115
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK1 plays a role in neuronal differentiation. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | PKc_CLK1_4 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22773841 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32075896 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4748702 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11244485 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28045888 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26807507 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9764678 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12533119 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4974602 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27541230 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2391097 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22695931 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/256700 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27415393 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 28.