http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID271112
Outgoing Links
Predicate | Object |
---|---|
abstract | Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase. Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis. |
title | PKc_DYRK |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32192954 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32845215 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5089950 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3096043 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11978442 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11206656 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12667016 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15965201 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33510856 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13207707 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11964711 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33510855 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15996285 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30905217 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3744599 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22590236 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5101837 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4474257 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2388947 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26194636 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
---|---|
has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ54BC9 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ09690 |
Total number of triples: 25.