http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID271105
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases. PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | PTKc_Src_Fyn_like |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20731320 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30843268 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30173186 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15293076 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9745660 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24646317 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1665299 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28818232 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29490705 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25398221 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23409690 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17991259 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23310880 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24038836 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20618191 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5811997 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24111452 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8437194 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19373338 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32152494 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23954667 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ02977 |
Total number of triples: 25.