http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270952

Outgoing Links

Predicate Object
abstract Catalytic domain of the Dual-specificity protein kinase, Myt1. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
title PKc_Myt1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18666453
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9281529
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2399862
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26140188
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4750275
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20757304
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20767049
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19436296
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9891290
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21311375
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7817104
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7749683
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10570778
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/977903
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21453845
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9NI63
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_004194
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ99640
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO18209
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_872629
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9ESG9

Total number of triples: 24.