http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270914

Outgoing Links

Predicate Object
abstract Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
title PK_eIF2AK_GCN2_rpt1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21443912
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28869664
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27534019
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24816787
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5093421
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25133351
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16695571
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3729352
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3729355
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8418433
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21447839
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29513836
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27539561
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1046636
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32921107
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15968905
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33552551
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26794431
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11969092
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24187785
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25125010
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_001013725
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9P2K8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9HGN1

Total number of triples: 27.