http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270914
Outgoing Links
Predicate | Object |
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abstract | Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
title | PK_eIF2AK_GCN2_rpt1 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21443912 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28869664 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27534019 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24816787 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5093421 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25133351 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16695571 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3729352 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3729355 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8418433 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21447839 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29513836 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27539561 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1046636 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32921107 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15968905 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33552551 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26794431 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11969092 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24187785 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25125010 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_001013725 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9P2K8 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9HGN1 |
Total number of triples: 27.