http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270772
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1 is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | STKc_ROCK1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11937314 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26807919 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15315439 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26129335 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19381106 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20727929 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27419668 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33534189 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27505742 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21393003 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22726238 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27488533 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22729824 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32848977 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20726525 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 28.