http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270770
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | STKc_nPKC_theta |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22720799 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21373596 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33437066 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12627762 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16585397 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16585396 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5018873 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7215333 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9158146 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13962842 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24800620 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/987361 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7795417 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12599758 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24116277 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 24.