http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270716
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of DNA-dependent protein kinase. DNA-PK is comprised of a regulatory subunit, containing the Ku70/80 subunit, and a catalytic subunit, which contains a NUC194 domain of unknown function, a FAT (FRAP, ATM and TRRAP) domain, a catalytic domain, and a FATC domain at the C-terminus. It is part of a multi-component system involved in non-homologous end joining (NHEJ), a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology. DNA-PK functions as a molecular sensor for DNA damage that enhances the signal via phosphorylation of downstream targets. It may also act as a protein scaffold that aids the localization of DNA repair proteins to the site of DNA damage. DNA-PK also plays a role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. DNA-PK is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases. |
| title | PIKKc_DNA-PK |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17291078 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28801169 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22043512 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21349542 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7874129 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32084537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24784313 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3037865 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22696308 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25129853 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5077432 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17299433 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29494040 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22629655 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19381551 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 24.