http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270707
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein. TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases. |
| title | PIKK_TRRAP |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17909715 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26808058 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29479754 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16575712 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9816798 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19359467 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3046428 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3044344 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18677318 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17222264 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32841991 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28733604 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15285403 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18593936 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 22.