http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270645
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase. PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | PTKc_Abl |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22077644 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1671203 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22077646 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4403273 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24104795 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19390607 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21999586 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21999585 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15295143 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12624041 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20618191 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20688439 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31509283 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15262327 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16635327 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10573362 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20698113 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13281321 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24766292 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4403289 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30828282 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9227016 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24107547 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12604183 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13847572 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7881648 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22084858 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5108019 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 65.