http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270577
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins. The subfamily includes cellular inhibitor of apoptosis protein 1 (c-IAP1) and c-IAP2. c-IAPs function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB)signaling, and oncogenesis. Unlike other apoptosis proteins (IAPs), such as XIAP, c-IAPs exhibit minimal binding to caspases and may not play an important role in the inhibition of these proteases. c-IAP1, also called baculoviral IAP repeat-containing protein BIRC2, IAP-2, RING finger protein 48, or TNFR2-TRAF-signaling complex protein 2, is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-kappaB signaling pathways in the cytoplasm. It can also regulate E2F1 transcription factor-mediated control of cyclin transcription in the nucleus. c-IAP2, also called BIRC3, IAP-1, apoptosis inhibitor 2 (API2), or IAP homolog C, also influences ubiquitin-dependent pathways that modulate innate immune signalling by activation of NF-kappaB. c-IAPs contain three N-terminal baculoviral IAP repeat (BIR) domains that enable interactions with proteins, a ubiquitin-association (UBA) domain that is responsible for the binding of binds polyubiquitin (polyUb), a caspase activation and recruitment domain (CARD) that serves as a protein interaction surface, and a RING domain at the carboxyl terminus that is required for ubiquitin ligase activity. |
| title | UBA_BIRC2_3 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16310941 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31347537 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10431923 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28703042 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16303307 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25147786 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13122876 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3706493 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24211664 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9116442 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6591142 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16006004 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23521985 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/237368 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30941395 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25147350 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26172080 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16306491 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32199154 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32259813 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 28.