http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID269868
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain. This subfamily is composed of NFE2 and NFE2-like proteins including NFE2-like 1 or NFE2-related factor 1 (NFE2L1 or Nrf1), NFE2L2 (or Nrf2), and NFE2L3 (or Nrf3). These are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. NFE2 functions in development; it is required for the proper development of platelets. The three Nrfs function in stress responses. Nrf2, the most extensively studied member of this subfamily, acts as a xenobiotic-activated receptor that regulates the adaptive response to oxidants and electrophiles. As the master regulator of the antioxidant defense pathway, it plays roles in the biology of inflammation, obesity, and cancer. Nrf1 is an essential protein that binds to the antioxidant response element (ARE) and is also involved in regulating oxidative stress. In addition, it also regulates genes involved in cell and tissue differentiation, inflammation, and hepatocyte homeostasis. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription. |
| title | bZIP_NFE2-like |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11995338 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4394837 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13414400 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20812191 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23542712 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5916314 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26145167 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2214360 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29608158 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18106105 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29333252 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15416380 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7307566 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28817232 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3850497 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21468324 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28199830 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2974459 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33664186 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4931979 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18116988 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1085249 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13400418 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32297983 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4515154 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30978176 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11348668 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8690952 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31576950 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15393233 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29596210 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 50.