http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID260073
Outgoing Links
Predicate | Object |
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abstract | Caspase activation and recruitment domain (CARD) found in IPS-1. Caspase activation and recruitment domain (CARD) found in IPS-1 (Interferon beta promoter stimulator protein 1), also known as CARDIF, VISA or MAVS. IPS-1 is an adaptor protein that plays an important role in interferon induction in response to viral infection. It is crucial in triggering innate immunity and in developing adaptive immunity against viral pathogens. The CARD of IPS-1 associates with the CARDs of two RNA helicases, RIG-I and MDA5, which bind viral DNA in the cytoplasm during the initial stage of intracellular antiviral response, leading to the induction of type I interferons. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes. |
title | CARD_IPS1 |
isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26797129 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11299399 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26133521 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19410528 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17398865 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20098977 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15314246 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31557529 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1067849 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1725707 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23267166 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13994624 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9951292 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24133999 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28883297 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13330069 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10557541 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17244585 |
type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Predicate | Subject |
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has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8VCF0 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ66HG9 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7Z434 |
Total number of triples: 24.