http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID260064
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Death domain found in Uncoordinated-5C. Death Domain (DD) found in Uncoordinated-5C (UNC5C). UNC5C is part of the UNC-5 homolog family. It is a receptor for the secreted netrin-1 and plays a role in axonal guidance, angiogenesis, and apoptosis. UNC5C plays a critical role in the development of spinal accessory motor neurons. Methylation of the UNC5C gene is associated with early stages of colorectal carcinogenesis. UNC5 proteins are transmembrane proteins with an extracellular domain consisting of two immunoglobulin repeats, two thrombospondin type-I modules and an intracellular region containing a ZU-5 domain, UPA domain and a DD. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes. |
| title | Death_UNC5C |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18047390 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14683253 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17142729 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6537325 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32229648 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33558197 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28871581 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31544570 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25540095 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31544589 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/6552865 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/33561250 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24133999 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24799953 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24094685 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26167230 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4387182 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18548865 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO95185 |
Total number of triples: 22.