http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID260036
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Caspase activation and recruitment domain found in Caspase-1 and related proteins. Caspase activation and recruitment domain (CARD) similar to those found in Caspase-1 (CASP1, ICE) and related proteins, including CARD-only proteins such as ICEBERG or CARD18, INCA (CARD17), CARD16 (COP1, PSEUDO-ICE), CARD8 (DACAR, NDPP1, TUCAN), and CARD12 (NLRC4), as well as ICE-like caspases such as CASP12, CASP5 (ICH-3) and CASP4 (TX, ICH-2). Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. CASP1 plays a central role in the cellular response to a wide variety of microbial and non-microbial stimuli, being activated by the inflammasome or the pyroptosome. CARD8 binds itself and the initiator caspase-9, interfering with the binding of APAF-1 and suppressing caspase-9 activation. CARD12 is a Nod-like receptor (NLR) that plays an important role in the innate immune response to Gram-negative bacteria. Caspase-4 (CASP4), -5 (CASP5), and -12 (CASP12) are inflammatory caspases implicated in inflammation and endoplasmic reticulum stress-induced apoptosis. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes. |
| title | CARD_CASP1-like |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24170284 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5146780 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11976542 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32243380 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31546242 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1649219 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17244585 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7195299 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26879743 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11981675 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26797129 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11981676 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9142991 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1569220 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24133999 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26207762 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21439416 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11981673 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11154187 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32256093 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10610506 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25520167 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11900292 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24144139 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11967844 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23267166 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20748505 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4379910 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 44.