http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID240107
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases from Bilateria, Dnmt1 and similar proteins. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the genome. These effects include transcriptional repression via inhibition of transcription factor binding, the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting, and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions. |
| title | BAH_Dnmt1_I |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16543817 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31386304 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17993485 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 11.