http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID239783
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the non-acetylated, cyclic route of ornithine biosynthesis. In this pathway, glutamate is first N-acetylated and then phosphorylated by NAGK to give phosphoryl NAG, which is converted to NAG-ornithine. There are two variants of this pathway. In one, typified by the pathway in Thermotoga maritima and Pseudomonas aeruginosa, the acetyl group is recycled by reversible transacetylation from acetylornithine to glutamate. The phosphorylation of NAG by NAGK is feedback inhibited by arginine. In photosynthetic organisms, NAGK is the target of the nitrogen-signaling protein PII. Hexameric formation of NAGK domains appears to be essential to both arginine inhibition and NAGK-PII complex formation. NAGK-C are members of the Amino Acid Kinase Superfamily (AAK). |
| title | AAK_NAGK-C |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9202627 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29474827 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12580108 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5775172 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27216575 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32102000 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3695668 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 53.