http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID239290
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the yeast ERV1p protein. QSOX oxidizes thiol groups to disulfides like PDI, however, unlike PDI, this oxidation is accompanied by the reduction of oxygen to hydrogen peroxide. QSOX is localized in high concentrations in cells with heavy secretory load and prefers peptides and proteins as substrates, not monothiols like glutathione. Inside the cell, QSOX is found in the endoplasmic reticulum and Golgi. The flow of reducing equivalents in a QSOX-catalyzed reaction goes from the dithiol substrate -> dithiol of the QSOX TRX domain -> dithiols of the QSOX ERV1p domain -> FAD -> oxygen. |
| title | PDI_a_QSOX |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/245254 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18603687 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/17219098 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28007809 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/12539219 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24022262 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15259969 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22621315 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19343410 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19287436 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3712615 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 25.