http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID213374
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha. Cyclic GMP-dependent Protein Kinase I (PKG1 or cGKI) is a Serine/Threonine Kinase (STK), catalyzing the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. They contain an N-terminal regulatory domain containing a dimerization/docking region and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. The dimerization/docking (D/D) domain is a leucine/isoleucine zipper that mediates both homodimerization and interaction with isotype-specific G-kinase-anchoring proteins (GKAPs). The D/D domain of the two variants (alpha and beta) differ, allowing for their targeting to different subcellular compartments and intracellular substrates. cGKI-alpha specifically binds to myosin light chain phosphatase targeting subunit (MYPT1) and the regulator of G-protein signaling-2 (RGS-2). cGKI-alpha activates the phosphatase activity of MYPT1, resulting in vasorelaxation. It increases the activity of RGS-2 toward G proteins, with implications in the downstream signaling for vasoconstrictive agents. |
| title | DD_cGKI-alpha |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30154504 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/244918 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28109981 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19445026 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2440679 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27458170 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/447399 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32240329 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/899271 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22053439 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/31568801 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22053442 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5112881 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22053436 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/299712 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20052160 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/27472200 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
Total number of triples: 25.