http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID213332
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Ras-GTPase Activating Domain of neurofibromin. Neurofibromin is the product of the neurofibromatosis type 1 gene (NF1) and shares a region of similarity with catalytic domain of the mammalian p120RasGAP protein and an extended similarity with the Saccharomyces cerevisiae RasGAP proteins Ira1 and Ira2. Neurofibromin has been shown to function as a GAP (GTPase-activating protein) which inhibits low molecular weight G proteins such as Ras by stimulating their intrinsic GTPase activity. NF1 is a common genetic disorder characterized by various symptoms ranging from predisposition for the development of tumors to learning disability or mental retardation. Loss of neurofibromin activity can be correlated to the increase in Ras-GTP concentration in neurofibromas of NF1 of patients, supporting the notion that unregulated Ras signaling may contribute to their development. |
| title | RasGAP_Neurofibromin |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20631642 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22066557 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3749220 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21231697 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7742717 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23389168 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/5664218 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14589932 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8577823 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/19231557 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15210040 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20731407 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ04690 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP97526 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP21359 |
Total number of triples: 18.