http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID212904
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Src homology 3 domain of Abl Interactor 1. Abi1, also called e3B1, is a central regulator of actin cytoskeletal reorganization through interactions with many protein complexes. It is part of WAVE, a nucleation-promoting factor complex, that links Rac 1 activation to actin polymerization causing lamellipodia protrusion at the plasma membrane. Abi1 interact with formins to promote protrusions at the leading edge of motile cells. It also is a target of alpha4 integrin, regulating membrane protrusions at sites of integrin engagement. Abi proteins are adaptor proteins serving as binding partners and substrates of Abl tyrosine kinases. They are involved in regulating actin cytoskeletal reorganization and play important roles in membrane-ruffling, endocytosis, cell motility, and cell migration. Abi proteins contain a homeobox homology domain, a proline-rich region, and a SH3 domain. The SH3 domain of Abi binds to a PxxP motif in Abl. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies. |
| title | SH3_Abi1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32077923 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1769657 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24043821 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18062995 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/26236689 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7870172 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4749202 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/28225225 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9911965 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11219312 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/1722950 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/22146015 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/14626783 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15227477 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/4426240 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18032378 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21412903 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18085244 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7299019 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13881394 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8CBW3 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9QZM5 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8IZP0 |
Total number of triples: 26.